2016 Fiscal Year Final Research Report
The role of the exercise related lactate on the corticospinal reorganization in the focal stroke rat.
| Project/Area Number |
15K16374
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Rehabilitation science/Welfare engineering
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| Research Institution | Showa University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
KUMADA Tatsuro 常葉大学, 保健医療学部, 教授 (00402339)
TSUTSUI Yoshihiro 常葉大学, 保健医療学部, 教授 (50073135)
AGATA Nobuhide 常葉大学, 保健医療学部, 講師 (00549313)
UMEMURA Kazuo 浜松医科大学, 医学部, 教授 (40232912)
HOKAMURA Kazuya 浜松医科大学, 医学部, 教授 (90436965)
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| Research Collaborator |
MORISHITA Saho 常葉大学, 健康プロデュース学部, 助手
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Keywords | 脳梗塞 / 運動負荷 / 乳酸 / 皮質脊髄路 |
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| Outline of Final Research Achievements |
We have studied the role of physical rehabilitation on neuronal reconstruction after cerebral infarction. To elucidate the relationship between motor dysfunction and deficits in local region of cerebral cortex, we established the focal stroke mouse and rat model, which only have small size of infarction in distinct cortical area such as motor cortex. To determine the conditions of physical rehabilitation using treadmill, we measured blood lactic acid levels, oxygen consumption and respiratory rate during exercises. As a result, increasing the intensity of treadmill exercise revealed the anaerobic and lactate threshold similar to human. Moreover, evaluation of the motor function during gait using kinesiological analysis enabled us to detect the subtle impairment of the limb's function. These results can open the possibility to access the relationship between the exercise related lactate and functional recovery.
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| Free Research Field |
リハビリテーション科学・福祉工学
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