Traumatic myositis ossificans - pathomechanism and treatment.

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K16488
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Sports science
• Research Institution: Osaka University
• Principal Investigator: TAKE YASUHIRO 大阪大学, 医学系研究科, 助教 (10745772)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: スポーツ外傷 / 骨化性筋炎 / 筋損傷 / 筋再生 / 異所性骨化

Outline of Final Research Achievements

To elucidate the pathomechanism of traumatic myositis ossificans, I developed a new animal model for analyses. Temporal and spatial transition of the histology of this model, which is difficult to examine in the clinical setting, suggested that myositis ossificans developed as a result of extensive fibrosis of the endomyosium and the perimyosium over myofiber regeneration after muscle damage, and not through direct differentiation of myofibers into the bone. Once myositis ossificans is developed, its maturation matters to consider the timing of return to sport and surgical excision, although there's no clear criterion. Micro-CT findings in this study showed no remarkable change after the mass became well-circumscribed and smoothly surfaced. Thus, such findings on CT may help determine the maturity of myositis ossificans in the clinical setting.

Free Research Field

スポーツ医学