Fused oligomers of a macrocycle with dynamic figure eight chirality

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K17818
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Organic chemistry
• Research Institution: Hokkaido University
• Principal Investigator: Katoono Ryo 北海道大学, 理学研究院, 助教 (60432142)
• Research Collaborator: TANAKA Yuki ; KAWAI Shunsuke ; KUSAKA Keiichi ; OBARA Yudai
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 動的キラリティ / マクロサイクル / テレフタルアミド / 縮環多量体

Outline of Final Research Achievements

I have newly designed a series of fused oligomers of macrocycles with dynamic figure eight chirality. Dynamic features in solution of these fused oligomers were investigated through NMR, UV and CD spectroscopy.
For fused oligomers, the barrier to dynamic interconversion between two helical conformations with M- or P-helicity followed a specific pattern similar to that of the original unit of a macrocycle. Complexation and chiroptical properties were dependent on the molecular shape, that is a manner of fusion. We found a new perspective on "chiral amplification". In a fused trimer or a tetramer, the helical-sense preference increased with the number of units. These finding was brought about by quantitative observation of the helical-sense preferences through NMR spectroscopy in solution.

Free Research Field

動的キラル化学