Direct C-N Bond Formation Using I-N Bonding Hypervalent Iodine

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K17819
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Organic chemistry
• Research Institution: Chiba University
• Principal Investigator: Moriyama Katsuhiko 千葉大学, 大学院理学研究院, 准教授 (00509044)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: アミノ化反応 / 複素環化合物 / 超原子価ヨウ素 / ハロゲン化 / ヨウ素

Outline of Final Research Achievements

We have developed the design of I-N bonding hypervalent iodine compounds and the direct amination of heterocycles using these compounds as low environmental load type transformation in this work. As a result, Csp2-Csp2 bromoamination, remote Csp2-Csp3 iodoamination, and catalytic 3-amination of indole derivatives were accomplished by handling I-N bonding hypervalent iodine compounds. Furthermore, synthesis of various amino-substituted indole derivatives from products of these transformations were succeeded.

Free Research Field

有機合成化学