Catalytic regioselective hetero-functionalizaiton of arenes

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K17821
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Organic chemistry
• Research Institution: Nagoya University
• Principal Investigator: Murakami Kei 名古屋大学, トランスフォーマティブ生命分子研究所(WPI), 准教授 (90732058)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: 芳香族アミノ化 / 銅触媒 / ルテニウム触媒 / スルホンイミド

Outline of Final Research Achievements

Functional molecules such as natural products, pharmaceuticals, and organic materials are indispensable. Arylamines are one of the most important structures of these functional molecules. However, direct synthesis of arylamine through C-H functionalization of arenes is difficult. In this research, development of new synthesis of arylamines are studied. At the starting point, we elucidated the mechanism of copper-catalyzed arylamine (arylimide) synthesis by using DFT calculations. Based on this finding, we have developed a new arylamine (arylimide) synthesis using photocatalyst. The scope of the reaction is wide enough to cover various polyaromatic hydrocarbons as well as heteroarenes.

Free Research Field

化学