2017 Fiscal Year Final Research Report
Discovery of novel RNA G-quadruplex ligands from a chemical library
| Project/Area Number |
15K17883
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Bio-related chemistry
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| Research Institution | Kumamoto University (2017)
Kyoto University (2015-2016) |
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Principal Investigator |
KATSUDA Yousuke 熊本大学, 大学院先端科学研究部(工), 助教 (50632460)
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| Co-Investigator(Renkei-kenkyūsha) |
UESUGI Motonari 京都大学, 化学研究所, 教授 (10402926)
SATO Shin-ichi 京都大学, 化学研究所, 准教授 (70534478)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | RNA G-quadrupelx / translation / screening |
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| Outline of Final Research Achievements |
The highlights of this study are: (i) the chemical library screening allowed us to discover a highly-selective RNA G-quadruplex stabilizer with a new chemical scaffold and physical property, (ii) the protein expression level of endogenous NRAS, a well-known proto-oncogene, was down-regulated with the stabilizer in living cells for the first time, and (iii) the RNA G-quadruplex stabilizer enabled the detection of a previously unidentified RNA G-quadruplex in 5’-UTR of NRAS.
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| Free Research Field |
生体機能関連化学
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