Preparation of thermoresponsive layered perovskites and protein separation based on dynamic control of their structures

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K17904
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Organic and hybrid materials
• Research Institution: Waseda University
• Principal Investigator: IDOTA Naokazu 早稲田大学, 理工学術院総合研究所(材料技術研究所), 助教 (60451796)
• Research Collaborator: SUGAHARA Yoshiyuki 早稲田大学, 理工学術院, 教授 (50196698)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: 温度応答性高分子 / 層状化合物 / 表面開始ATRP / 金属配位 / ナノシート / タンパク質吸着

Outline of Final Research Achievements

Thermoresponsive copolymer-modified inorganic nanosheets bearing N-isopropylacrylamide (NIPAAm) and (N,N-dicarbonylmethyl)aminomethylstyrene (DCAS) were prepared using layered perovskite HLaNb2O7・xH2O (HLN) through surface-initiated atom transfer radical polymerization (SI-ATRP) at the interlayer followed by their exfoliation. Their thermoresponsibility, metal-coordination ability and protein accessibility were evaluated for development of functional protein separation system. Thermoresponsive phase transition and effective coordination to Cu ions were successfully investigated using the modified nanosheets, although no reproducible results of temperature-dependent protein adsorption on the surfaces were obtained.

Free Research Field

無機-有機ハイブリッド、バイオマテリアル