2017 Fiscal Year Final Research Report
Functional anatomy of the medial preoptic area
| Project/Area Number |
15K18364
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Nerve anatomy/Neuropathology
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| Research Institution | Toho University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | MPOA / 養育行動 / 性行動 / 攻撃行動 / 性ホルモン受容体 / c-Fos |
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| Outline of Final Research Achievements |
The medial preoptic area (MPOA) is located at the anterior portion of the hypothalamus. This area has been known to be the brain center for the widely diverse behaviors. However, little is known for their function and anatomy because of the heterogeneity and complexity of the MPOA anatomy. We reviewed the anatomy of the MPOA subregions by using molecular markers, and developed the atlas of the MPOA. We also reported the gonadal steroid hormone receptor expressions in the MPOA with the molecular marker expression. Based on these results, we assessed the neural activity during various instinctive behaviors by means of histological analyses of c-Fos expression. In addition, using cre-loxp mediated manipulation of the neural activity, the responsible cell groups for regulating various behavior were determined.
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| Free Research Field |
神経解剖学
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