Analysis of reprogrammed metabolism by PGAM in cancer stem cell model

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K18404
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Tumor biology
• Research Institution: Kanazawa University
• Principal Investigator: Kohno Susumu 金沢大学, がん進展制御研究所, 助教 (30625463)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: PGAM / 糖代謝 / RB / がん幹細胞

Outline of Final Research Achievements

Inactivation of the tumor suppressor gene RB is frequently observed in cancer progression.　We analyzed the model lacking RB additionally and found that thyroid C cells of RB ・ p53-deficient mice acquire high undifferentiated property. In addition, we also found that cancer stem cell-like populations appear due to the additional deficiency of RB in p53 deficient cancer cells. In this study, we focused on the metabolism of cancer stem cell - like population and analyzed its dynamics, revealing that PGAM is necessary for maintaining the undifferentiated state of cancer stem cell - like population. Furthermore, it was revealed that regulation of PGAM expression by RB is mediated through histone demethylase.

Free Research Field

腫瘍生物学