2016 Fiscal Year Final Research Report
An investigation of the molecular mechanisms of IMiDs induced IRF4 and MYC downregulation in multiple myeloma
| Project/Area Number |
15K18418
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Tumor biology
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| Research Institution | Tokyo Medical University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Keywords | 多発性骨髄腫 / IMiDs / IRF4 / MYC / 転写因子 / がん |
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| Outline of Final Research Achievements |
IRF4 and MYC are known as essential genes for survival of multiple myeloma cells. Immunomodulatory drugs (IMiDs) promote the downregulation of IRF4 and MYC expression in multiple myeloma cells. However, the underlying mechanisms are not entirely clear.
The purpose of this study was to elucidate the molecular mechanisms of IMiDs induced IRF4 and MYC downregulation. In this study, I attempted to identify protein factors that regulate transcription of IRF4 and MYC. Our results suggest that five genes identified in this study are involved in the expression of IRF4 and MYC and/or IMiDs induced growth inhibition in multiple myeloma cells.
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| Free Research Field |
分子生物学
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