2016 Fiscal Year Final Research Report
Molecular mechanism of tumour malignancy via exosomes
| Project/Area Number |
15K18424
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Tumor biology
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| Research Institution | Kanagawa Cancer Center Research Institute |
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Principal Investigator |
Daisuke Hoshino 地方独立行政法人神奈川県立病院機構神奈川県立がんセンター(臨床研究所), その他部局等, 副技幹・主任研究員 (30571434)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Keywords | がん / 浸潤 / 細胞運動 |
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| Outline of Final Research Achievements |
Here, I identified tumour malignancy promoting exosome cargoes using cell biology and mathematical modeling. First, I identified the proteins that is activated by exosomes. Next, to visualized the molecular interactions between these proteins, we performed network analysis.
Finally, I identified multiple key proteins by statistical analysis and confirmed these proteins regulate tumour malignancies in cell biology level.
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| Free Research Field |
がん生物学
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