2017 Fiscal Year Final Research Report
Elucidation of the mechanism underlying the formation of neuromuscular synapse
| Project/Area Number |
15K18500
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Functional biochemistry
|
|---|
| Research Institution | The University of Tokyo |
|---|
Principal Investigator |
Ueta Ryo 東京大学, 医科学研究所, 助教 (10445025)
|
|---|
| Research Collaborator |
NAGATOISHI Satoru 東京大学, 医科学研究所, 特任准教授 (30550248)
|
|---|
| Project Period (FY) |
2015-04-01 – 2018-03-31
|
| Keywords | 神経筋シナプス |
|---|
| Outline of Final Research Achievements |
Neuromuscular Junction (NMJ) is an essential synapse between motor neuron and skeletal muscle. The NMJ formation requires muscle specific receptor kinase MuSK and "NMJ formation signal" that is driven by the activation of MuSK. To elucidate the molecular mechanisms underlying NMJ formation, we have constructed the high-throughput screening system and identified candidate molecules that are involved in "NMJ formation signal."
|
| Free Research Field |
分子生物学
|
