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2016 Fiscal Year Final Research Report

Analysis of the novel mode of action of fungicide "protein prenylation" that has been indicated by whole genome analysis

Research Project

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Project/Area Number 15K18655
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Plant protection science
Research InstitutionThe University of Shiga Prefecture

Principal Investigator

Izumitsu Kosuke  滋賀県立大学, 環境科学部, 助教 (20579263)

Project Period (FY) 2015-04-01 – 2017-03-31
Keywords殺菌剤 / プレニル化 / ゲラニルゲラニルトランスフェラーゼ
Outline of Final Research Achievements

In our previous study, it was suggested that tolnifanide resistance gene encodes geranylgeranyl transferase (GGT1). In this study, we introduced the mutated GGT1 gene (C406Y) into the wild-type strain of Bipolaris maydis. The transformants expressing mutated GGT1 showed highly resistance to tolnifanide. We attempted gene knockout of GGT1 but no gene-disrupted strain was obtained, suggesting that GGT1 is essential gene in B. maydis. As a result of examining the localization of RHO1, predicted to undergo geranylgeranylation modification, it was suggested that tolnifanide may inhibit localization of RHO1.

Free Research Field

菌類分子遺伝学、植物病理学、農薬科学

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Published: 2018-03-22  

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