Molecular mechanisms for proliferation-differentiation switch of skeletal muscle stem cells in response to metabolic signaling

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K18766
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Animal production science
• Research Institution: The University of Tokyo
• Principal Investigator: Yoneyama Yosuke 東京大学, 大学院農学生命科学研究科(農学部), 特任研究員 (10748289)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: インスリン様成長因子 / インスリン受容体基質 / アセチル化

Outline of Final Research Achievements

Myogenic precursor cells contribute to the development of skeletal muscle as well as regeneration after injury. Insulin-like growth factor is an important hormone that regulates the function of myogenic precursor cells including proliferation and differentiation. In this study, we showed that insulin receptor substrate, a mediator of insulin-like growth factor signaling, is acetylated in response to metabolic activity of myogenic precursor cells. We identified a set of enzymes that acetylate or deacetylate insulin receptor substrate. Our study revealed a potential mechanism in which insulin-like growth factor signaling is modulated during myogenesis to coordinate the fate decision of myogenic precursor cells.

Free Research Field

分子細胞生物学