Analysis of genetic diversity and host-specificity of non-primate hepacivirus

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K18779
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Veterinary medical science
• Research Institution: University of Yamanashi
• Principal Investigator: TANAKA Tomohisa 山梨大学, 大学院総合研究部, 特任助教 (30585310)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: へパシウイルス / 翻訳 / ゲノム複製 / 多様性

Outline of Final Research Achievements

Non-primate hepacivirus (NPHV) is thought to share the ancestor with hepatitis C virus (HCV), which is an important viral model for elucidating the origin, pathogenicity or host-tropism of HCV. However, the epidemiological or virological evidence is still poor. In this study, we isolated NPHV from some endemic species in Japan and phylogenetically analyzed them in order to elucidate the genetic diversity of NPHV. Moreover, we investigated the mechanisms of equine hepacivirus (EHcV) 5’ UTR in IRES-dependent translation initiation and the association of EHcV 5’ UTR with miR-122-indepdendent viral replication.

Free Research Field

ウイルス学