Establishment of new immunotherapy targeting novel co-inhibitory molecule DC-HIL against canine malignant melanoma

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K18798
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Veterinary medical science
• Research Institution: Nippon Veterinary and Life Science University
• Principal Investigator: Tamura Kyoichi 日本獣医生命科学大学, 獣医学部, 助教 (00722282)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: 犬 / 悪性黒色腫 / 免疫抑制 / DC-HIL

Outline of Final Research Achievements

Our aim of this project is the establishment of new immunotherapy targeting novel co-inhibitory molecule DC-HIL against canine malignant melanoma. DC-HIL expressed by malignant melanoma cells acted in an inhibitory manner in the tumor immune reaction and showed that tumor growth was promoted. In a case of canine malignant melanoma, we found that DC-HIL in which tumor cells are expressed is involved in the immunosuppression of tumor-bearing individuals and that the prognosis may be poor. In addition, we revealed that anti-dog DC-HIL antibody can inhibit immunosuppressive function by DC-HIL expressed by canine malignant melanoma cells.

Free Research Field

獣医学