Screening of the novel target for cancer therapy based on the mechanisms of natural compounds

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K18821
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Applied molecular and cellular biology
• Research Institution: National Cardiovascular Center Research Institute (2017); Kyushu University (2015-2016)
• Principal Investigator: Kumazoe Motofumi 国立研究開発法人国立循環器病研究センター, 研究所, 特任研究員 (70737212)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: cGMP / Caner / EGCG

Outline of Final Research Achievements

Green tea polyphenol Epigallocatechin-3-O-gallate has anti-cancer effect. Several clinical trials show its anti-cancer effect, however, little is known its mechanisms. We previously reported that cGMP mediates anti-cancer effect of EGCG.Because EGCG also have strong suppressing effect on cancer stem cell properties, we hypothesized that cGMP itself has strong inhibitory effect on cancer stem cell properties. Our data shows some kind of cGMP inducer shows strong inhibitory effect on cancer stem cell properties.

Free Research Field

天然物質の作用機構解明