Development of magnetically guided M2 macrophages-based cell therapy for inflammatory bowel disease

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K18851
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Physical pharmacy
• Research Institution: Ritsumeikan University
• Principal Investigator: Kono Yusuke 立命館大学, 薬学部, 助教 (60732823)
• Research Collaborator: FUJITA TAKUYA 立命館大学, 薬学部, 教授 (00247785) ; KONISHI SATOSHI 立命館大学, 理工学部, 教授 (50288627)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: 磁場応答性リポソーム / 細胞送達システム / M2型マクロファージ

Outline of Final Research Achievements

In order to develop the macrophages-based cell therapy for inflammatory bowel disease, it is necessary to construct the colon-selective cell delivery system. In this study, we have succeeded in efficiently delivering magnetic liposomes/plasmid DNA complexes-introduced macrophages to the region where an external magnetic field is exposed. In addition, we have demonstrated that these macrophages exhibit anti-inflammatory M2 phenotype, and have an ability to convert the phenotype of surrounding macrophages to M2.

Free Research Field

医歯薬学