2016 Fiscal Year Final Research Report
Alzheimer's disease-related peptides as a biomarker for diagnosis in early stage Alzheimer's disease
| Project/Area Number |
15K18854
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biological pharmacy
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| Research Institution | Hokkaido University |
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Principal Investigator |
HATA Saori 北海道大学, 薬学研究院, 助教 (40581012)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Keywords | アルツハイマー病 / バイオマーカー |
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| Outline of Final Research Achievements |
Alzheimer’s disease (AD) is the most common senile dementia. AD pathology in the brain is estimated to progress over years prior to detectible cognitive impairment. Biomarkers for early detection of AD may be necessary to develop effective AD treatment. In this study, we identified p3-Alc peptides as a useful indicator of AD pathogenesis, and developed the sELISA system of the peptides. Quantitative analyses of p3-Alc peptides indicate that p3-Alc may be useful biomarker for early diagnosis of AD.
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| Free Research Field |
神経科学
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