2016 Fiscal Year Final Research Report
The analysis of neudesin, a secretory molecule, for developing an anti-obesity drug
| Project/Area Number |
15K18863
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biological pharmacy
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| Research Institution | Nagoya University (2016)
Kobe Pharmaceutical University (2015) |
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Principal Investigator |
Ohta Hiroya 名古屋大学, 環境医学研究所, 助教 (40638988)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Keywords | neudesin / ノルアドレナリン / 交感神経系 / 脂肪組織 |
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| Outline of Final Research Achievements |
We previously reported that the neudesin KO mice were resistant to diet-induced obesity. neudesin KO mice showed increased energy expenditure due to increased sympathetic nervous activity. We newly found that recombinant neudesin protein acted on differentiated PC12 cells to suppress tyrosine hydroxylase (Th), which is a rate-limiting enzyme of noradrenaline synthesis. We also found that neudesin directly acted on white adipocytes to suppress adrenaergic stimuli on adipocytes.
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| Free Research Field |
分子生物学
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