2016 Fiscal Year Final Research Report
TMEPAI family inhibits proliferation of malignant mesothelioma cells.
| Project/Area Number |
15K18866
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biological pharmacy
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| Research Institution | Showa Pharmaceutical University |
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Principal Investigator |
Nakano Naoko 昭和薬科大学, 薬学部, 助教 (50733218)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Keywords | C18ORF1 / YAP / TMEPAI family / Hippo pathway / TGF-βsignal |
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| Outline of Final Research Achievements |
Integration between TGF-b and YAP signaling pathways has been reported in malignant mesothelioma (MM) cells. We found that YAP signal could be negatively controlled by TMEPAI family which we have already identified as a negative regulator of TGF-b signaling. In addition, we identified that the PY motifs in TMEPAI family play an important role in their interaction with YAP via its WW domains. We also found that TMEPAI family inhibits proliferation of MM cells.
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| Free Research Field |
分子細胞生物学
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