2017 Fiscal Year Final Research Report
Physiological regulation of lipid homeostasis by prostaglandin EP4 receptor
| Project/Area Number |
15K18875
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pharmacology in pharmacy
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| Research Institution | Kumamoto University |
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Principal Investigator |
Inazumi Tomoaki 熊本大学, 大学院生命科学研究部(薬), 助教 (80746503)
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| Research Collaborator |
YAMADA Kiyotaka
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | プロスタグランジン受容体 / 脂質代謝 |
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| Outline of Final Research Achievements |
In this study, we found that prostaglandin (PG) E2-EP4 receptor pathway regulates physiological lipid distribution by changing the lipid accumulation balance between adipose tissue and liver. Adipocyte-specific EP4 KO mice showed increased adiposity like in global KO mice, suggesting that PGE2 mainly acts on EP4 receptor in adipocyte. Moreover, EP4 agonist treatment to diet-induced obesity mice changed the lipid distribution in several tissues. These results show the possibility that EP4 receptor may be useful as a therapeutic target of dyslipidemia.
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| Free Research Field |
生化学、分子生物学
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