Mechanism underlying upregulation of calcium-sensing receptor in pulmonary hypertension

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K18881
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Pharmacology in pharmacy
• Research Institution: Kinjo Gakuin University
• Principal Investigator: YAMAMURA Aya 金城学院大学, 薬学部, 助教 (40633219)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: 肺高血圧症 / カルシウム感受性受容体 / イオンチャネル / 肺動脈 / 平滑筋 / カルシウムシグナル

Outline of Final Research Achievements

Pulmonary arterial hypertension is an intractable disease that pulmonary arterial pressure chronically increases due to vascular impairment. We found that upregulation of calcium-sensing receptor in pulmonary arterial smooth muscle cells is involved in pathogenesis of pulmonary arterial hypertension. In this study, we showed that functional coupling of calcium-sensing receptor with TRPC6 channel and usefulness of calcium-sensing receptor antagonists for pulmonary arterial hypertension. Our findings provide novel therapeutic strategies for pulmonary arterial hypertension.

Free Research Field

薬理学