2016 Fiscal Year Final Research Report
Search for compounds that supress the effects of low-dose methylmercury
| Project/Area Number |
15K18887
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Natural medicines
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| Research Institution | Kitasato University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Keywords | メチル水銀 / 抗メチル水銀薬 / サポニン化合物 |
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| Outline of Final Research Achievements |
Methylmercury (MeHg) did not exacerbate the pathology of food allergy and atopy model mice in which the immune response is enhanced.
Herbal derived compounds were explored about inhibitory effects of methylmercury (MeHg) toxicity. SA006 treatment significantly increased cell viability and suppressed cellular intake of MeHg in MeHg exposure cells. To verify the therapeutic effects of these compounds on the MeHg toxicity, mice were administered MeHg with/without pretreatment of SA006 5 times a week for 4 weeks. SA006 significantly decreased MeHg accumulation in liver, kidney, spleen, cerebrum and cerebellum. These results suggested SA006 inhibits MeHg toxicity by suppressing an accumulation of MeHg in organs.
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| Free Research Field |
毒性学
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