2017 Fiscal Year Final Research Report
Effect of genetic polymorphisms of azathioprine-metabolizing enzymes on response to rheumatoid arthritis treatment
Project/Area Number |
15K18933
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Medical pharmacy
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Research Institution | Keio University |
Principal Investigator |
AOMORI Tohru 慶應義塾大学, 薬学部(芝共立), 准教授 (40620802)
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Research Collaborator |
TSUCHIYA Ayumi
SAKAMOTO Mami
TAKEUCHI Arisa
ISHIOKA Eriko
KANEKO Yuko
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Project Period (FY) |
2015-04-01 – 2018-03-31
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Keywords | アザチオプリン / 関節リウマチ / inosine triphosphatese / ITPA |
Outline of Final Research Achievements |
The aim of this study was to evaluate the association between the genetic polymorphisms of azathioprine (AZA) -metabolizing enzymes and their influence on rheumatoid arthritis treatment. As a result of comparison between patients with and without mutation in inosine triphosphatase (ITPA), one of the metabolic enzymes of AZA, the dosage of AZA was 0.851±0.302 mg/kg/day in the mutant group, while 1.24±0.463 mg/kg/day in the wild type group. On the other hand, there was no significant difference between the two groups in the change of DAS28 during 6 months, which is an index of the therapeutic effect. As a conclusion, patients with ITPA mutation had equivalent therapeutic effect with a lower dose compared with patients without the mutation.
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Free Research Field |
臨床薬学
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