Adipose insulin signaling regulated by brain KATP channel

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K18977
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Environmental physiology(including physical medicine and nutritional physiology)
• Research Institution: National Center for Global Health and Medicine
• Principal Investigator: OGURA KOHEI 国立研究開発法人国立国際医療研究センター, 研究所・感染症制御研究部, 上級研究員 (00586612)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: グルコース取り込み / インスリン応答 / KATPチャネル

Outline of Final Research Achievements

ATP-sensitive potassium (K(ATP)) channel is critical in metabolism control. Previous reports showed that insulin-dependent glucose uptake is enhanced in adipose tissues of KATP channel knockout (KO) mice compared with that in wild-type mice. Insulin stimulated in vivo interaction of Akt and unknown factor in adipose tissues. The interaction was enhanced dependent on amount of injected insulin. Akt2 mainly played role for the interaction in adipose tissues of KO mice. Mass spectrometry analysis showed 14-3-3 family proteins are candidates for the interaction with Akt2.

Free Research Field

細胞生物学