thermogenic pathways of progesterone and its metabolites in rats

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K18979
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Environmental physiology(including physical medicine and nutritional physiology)
• Research Institution: Nippon Medical School
• Principal Investigator: Iwata Kinuyo 日本医科大学, 医学部, 講師 (00582991)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: プロゲステロン / 体温上昇

Outline of Final Research Achievements

This study aims to determine thermogenic pathways of progesterone in female rats. Rectal temperatures were measured, but values were a lack of stability. Therefore, an implantable thermometer was utilized. To study whether progesterone induces thermogenesis, progesterone was subcutaneously injected or a progesterone-containing silicon tube was implanted in ovariectomized rats. Progesterone did not affect body temperatures. Our results did not coincide with previous studies. We will try other methods and study effects of its metabolite on thermogenesis.

Free Research Field

生殖神経内分泌