2016 Fiscal Year Final Research Report
Physiological role and molecular mechanism of early Golgi quality control system
| Project/Area Number |
15K19002
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General medical chemistry
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| Research Institution | Gunma University |
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Principal Investigator |
Hara Taichi 群馬大学, 生体調節研究所, 准教授 (00392374)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Keywords | タンパク質品質管理機構 / 初期胚発生 / ゴルジ体 / 細胞膜タンパク質 / 小胞体 / 疾患関連変異膜タンパク質 / 遺伝子欠損マウス / Rer1 |
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| Outline of Final Research Achievements |
Rer1 has been suggested to be involved in the quality control of plasma membrane proteins in the Golgi apparatus. However, its physiological roles and molecular mechanisms in mammal remained to be elucidated. In this study, we generated Rer1 deficient mice and analyzed the phenotype. We confirmed that Rer1 deficient mice were embryonic lethal, indicating that Rer1 has an essential role in mouse early development. We also found that Rer1 regulates the ER retention of some kind of disease-associated membrane proteins.
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| Free Research Field |
細胞生物学
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