2016 Fiscal Year Final Research Report
Roles of TGF-beta in HTLV-1-infected T cells
Project/Area Number |
15K19020
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Pathological medical chemistry
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Research Institution | Tokyo Medical and Dental University |
Principal Investigator |
Nagano Yoshiko 東京医科歯科大学, 大学院医歯学総合研究科, 助教 (10723819)
|
Project Period (FY) |
2015-04-01 – 2017-03-31
|
Keywords | HTLV-1 / ATL / TGF-beta / IL-10 |
Outline of Final Research Achievements |
Adult T cell Leukemia (ATL) is caused by infection with Human T cell Leukemia Virus-1 (HTLV-1). HTLV-1-specific immune responses are suppressed in ATL, and infected cells themselves are reported to be regulatory T cell-like. In this study, we investigated the regulation of HTLV-1-infected cells by immune suppressive cytokines, TGF-beta and IL-10. We found that the infected cell lines tested responded to TGF-beta weakly whereas IL-10 may promote proliferation of HTLV-1-infected cells.
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Free Research Field |
腫瘍生物学
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