Exploration study on gene therapeutic targets and biomarkers for early diagnosis using an impaired glucose tolerance zebrafish model

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K19074
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Experimental pathology
• Research Institution: Mie University
• Principal Investigator: Zang Liqing 三重大学, 地域イノベーション学研究科, 助教 (10437105)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: 2型糖尿病 / ゼブラフィッシュ / 遺伝子抑制 / 治療標的遺伝子

Outline of Final Research Achievements

Impaired glucose tolerance is a pre-diabetic state of type 2 diabetes mellitus (T2DM) that is associated with either insulin resistance, low insulin production or both. Early detection and therapeutic treatment of impaired glucose tolerance is now attracting attention as a prophylactic treatment strategy. In this study, we developed a T2DM model zebrafish and identified novel therapeutic targets gene (such as hmox1) by RNA-seq analysis. Knockdown study of these genes ameliorated the T2DM phenotypes including glucose intolerance.

Free Research Field

医学