2016 Fiscal Year Final Research Report
Elucidation of the novel molecular mechanisms of proinflammatory cytokine production regulated by metabolism-related molecules
| Project/Area Number |
15K19077
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Experimental pathology
|
|---|
| Research Institution | Wakayama Medical University |
|---|
Principal Investigator |
Sasaki Izumi 和歌山県立医科大学, 先端医学研究所, 助教 (80611037)
|
|---|
| Project Period (FY) |
2015-04-01 – 2017-03-31
|
| Keywords | コレラ毒素 |
|---|
| Outline of Final Research Achievements |
Cholera toxin (CT) is strong immune adjuvant, which can induce Th17 responses. However, the mechanisms remain unclear. We have found that CT plus lipopolysaccharides (LPS) can synergistically induce IL-1 beta production. Our aim is to elucidate the mechanism of this IL-1 beta production. Integrated analysis of transcriptome and metabolome revealed that CT and CT plus LPS activated arginine metabolic pathway and histamine synthetic pathway, respectively. In this research, we have showed that the physiological role of these metabolic pathway in CT plus LPS-induced IL-1 beta production.
|
| Free Research Field |
免疫学
|
