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2017 Fiscal Year Final Research Report

Elucidation whether innate-like lymphocytes are related with immunological memory during malaria

Research Project

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Project/Area Number 15K19085
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Parasitology (including sanitary zoology)
Research InstitutionKyorin University

Principal Investigator

INOUE Shin-Ichi  杏林大学, 医学部, 学内講師 (20466030)

Research Collaborator YOKOTA Natsuki  杏林大学, 医学部, 実験助手
Project Period (FY) 2015-04-01 – 2018-03-31
KeywordsγδT細胞 / マラリア / 免疫記憶
Outline of Final Research Achievements

Immunological memory is a crucial phenomenon for protective immunity against a variety of pathogens. However, it remains largely unknown the mechanism how immunological memory against malaria develops and maintains during malaria. Thus, to elucidate the mechanism, we used mice model of malaria. We have shown that gamma delta T cells, which is a innate-like lymphocyte, have crucial functions for protective immunity against malaria during primary infection with Plasmodium parasites. In this study, we suggest that gamma delta T cell would be involved in immunological memory against malaria.

Free Research Field

感染免疫

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Published: 2019-03-29  

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