Identification of a novel receptor and signal transduction for chemokine TARC

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K19141
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Immunology
• Research Institution: National Institute of Infectious Diseases
• Principal Investigator: Hiyoshi Masateru 国立感染症研究所, 血液・安全性研究部, 研究員 (40448519)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: ケモカイン / レセプター

Outline of Final Research Achievements

Chemokine TARC is involved in allergic inflammatory reactions. it is known that CCR4 is the only receptor of TARC. Therefore, identification of a novel TARC receptor and signal transduction provides a new insight into allergic inflammatory response. In this study, we aimed to identify a novel TARC receptor from a cell in which TARC binds to cell surface without the expression of CCR4. we purified proteins from the cell using the FLAG affinity chromatography and identified three proteins bound to TARC-Flag protein by mass spectrometry. Moreover, the three proteins are expressed in immune cells and localized to cell surface, suggesting that the three proteins are candidates for a novel TARC receptor.

Free Research Field

細胞生物学