Mucosa-associated lymphoid tissue organogenesis by unique inducer cell subsets.

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K19142
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Immunology
• Research Institution: National Institutes of Biomedical Innovation, Health and Nutrition
• Principal Investigator: Takahiro Nagatake 国立研究開発法人医薬基盤・健康・栄養研究所, 医薬基盤研究所 ワクチンマテリアルプロジェクト, 研究員 (80608737)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: 粘膜関連リンパ組織形成 / リンパ組織誘導細胞 / パイエル板 / NALT / TALT / iBALT

Outline of Final Research Achievements

Mucosa-associated lymphoid tissues develop in various mucosal surfaces and play an important role in host defense. In this study, we found that respiratory lymphoid tissues develop using unique developmental programs that is different from intestinal and lacrimal lymphoid tissue programs. Further, we found that antibody response and allergic symptoms was normally induced in the absence of nasopharynx-associated lymphoid tissue, suggesting the presence of lymphoid tissue-independent immune systems in the upper respiratory tract. These findings indicate that respiratory immune system show uniqueness in tissue development and immune function which is a target of the development of effective nasal vaccine.

Free Research Field

粘膜免疫学