Contribution of LTBR signaling for development of COPD

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K19172
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Laboratory medicine
• Research Institution: The University of Tokyo
• Principal Investigator: Mikami Yu 東京大学, 医学部附属病院, 特任臨床医 (50732806)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: COPD / 肺気腫 / マウスモデル / LTBR / マイクロアレイ

Outline of Final Research Achievements

Recently, Chronic Obstructive disease(COPD) is recognized as a systemic inflammatory disease. A variety of mechanisms of the inflammation in COPD are reported; however, the therapeutic approach for the inflammation is not sufficient. The purpose of this project is to investigate the roles of Tumor necrosis factor superfamily member 14 (LIGHT) and Lymphotoxin beta receptor (LTβR) signaling in COPD through both basic cell researches and development of a COPD animal model. We developed the COPD mice model, and LTβR was induced in the lung of COPD model mice. Our findings suggested that LTβR might be a disease marker and therapeutic target of COPD.

Free Research Field

呼吸器内科