Serum irisin and obesity, diabetes mellitus, and atherosclerosis

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K19224
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Epidemiology and preventive medicine
• Research Institution: Shimane University (2016); Shiga University of Medical Science (2015)
• Principal Investigator: Hisamatsu Takashi 島根大学, 医学部, 准教授 (60710449)
• Research Collaborator: MIURA Katsuyuki 滋賀医科大学, 社会医学講座公衆衛生学部門, 教授 (90257452) ; UESHIMA Hirotsugu 滋賀医科大学, アジア疫学研究センター, 特任教授 (70144483) ; FUJIYOSHI Akira 滋賀医科大学, 社会医学講座公衆衛生学部門, 准教授 (10567077)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: イリシン / 疫学 / 肥満 / 糖尿病 / 動脈硬化

Outline of Final Research Achievements

Irisin is a newly discovered myokine. We aimed to examine to the association of serum irisin and obesity, diabetes mellitus, and atherosclerosis. In a community-based apparently healthy adults aged 40-79 years, serum irisin was inversely associated with obesity and lipid indices. In addition, serum irisin was inversely associated with progression of coronary artery calcification independent of confounders including obesity, lipid, and diabetes parameters. Future studies are needed to assess whether irisin is protectively associated with cardiometabolic disease.

Free Research Field

疫学（循環器病）