Exacerbating effects of insulin resistance on Alzheimer's disease

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K19279
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: General internal medicine(including psychosomatic medicine)
• Research Institution: Chiba University
• Principal Investigator: Izuo Naotaka 千葉大学, 大学院医学研究院, 日本学術振興会特別研究員(PD) (50722261)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: アルツハイマー病 / 糖尿病 / インスリン抵抗性 / 行動解析

Outline of Final Research Achievements

Insulin resistance is one of risk factors of Alzheimer’s disease (AD). I investigated an exacerbating effects of insulin resistance on AD by phenotypic analyses on model mice. By crossbreeding of insulin resistant mice knocked in mutant insulin receptor and AD model mice, we generated insulin resistant AD model mice. This double knockin mice exhibited deficit of long term memory, decreased anxiety sensitivity and depression in behavioral analyses without affecting senile plaque pathology. By oral administration of Omega-3 fatty acids, insulin resistant AD model mice recovered from psychological symptoms, especially depression. These results would contribute to developing preventive and therapeutic strategies on AD.

Free Research Field

神経老化薬学