The development of new treatments using probiotics-derived molecules for intestinal fibrosis based on an analysis of its mechanisms

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K19306
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Gastroenterology
• Research Institution: Asahikawa Medical College
• Principal Investigator: Kashima Shin 旭川医科大学, 医学部, 助教 (10548655)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: プロバイオティクス / 消化管線維化 / ポリリン酸 / Ferrichrome / マクロファージ

Outline of Final Research Achievements

I explored the effective molecules derived from probiotic conditioned-media and identified ferrichrome as a candidate anti-fibrotic molecule. However, ferrichrome did not exhibit an anti-fibrotic function, although it did have a strong anti-tumor function. A bioactive polyphosphate derived from Lactobacillus brevis exhibited an anti-inflammatory function through the regulation of TLR4-IFNα/β-JAK/STAT signaling. I have not identified new materials derived from probiotics in this study but will continue to search for new anti-inflammatory antifibrosis materials derived from effective molecules exhibiting anti-fibrotic activity in probiotic conditioned-media.

Free Research Field

消化器内科学