The analysis of the host innate immunity induced upon hepatitis virus infection and its inhibitory mechanism by virus protein

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K19316
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Gastroenterology
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: Nitta Sayuri 東京医科歯科大学, 医学部, プロジェクト助教 (20527056)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: ウイルス性肝炎 / 自然免疫 / 肝疾患治療 / 臨床病態解析 / 細胞・組織

Outline of Final Research Achievements

In the hepatitis C virus (HCV) study, we demonstrated that the HCV-NS4B protein function to suppress interferon (IFN) activity may related to the effect of IFN therapy to chronic hepatitis C by the analysis using blood samples from patients infected with HCV. In the hepatitis B virus (HBV) study, we demonstrated that RIG-I dependent IFN signal pathway is one of the important innate immune signaling induced during HBV infection. Furthermore, we indicated that interferon stimulated genes induced by IFN is suppressed by HBV. These results above are important and contribute to understand and clarify the mechanisms of the sustained virus infection and the resistance to IFN therapy.

Free Research Field

ウイルス性肝炎