Elucidation of the role of Zinc transporter in intestinal stem cell maintenance.

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K19319
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Gastroenterology
• Research Institution: University of Toyama
• Principal Investigator: Ohashi Wakana 富山大学, 大学院医学薬学研究部(医学), 助教 (50381596)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: 腸管上皮細胞 / 亜鉛トランスポーター / 腸管上皮幹細胞

Outline of Final Research Achievements

Zinc transporters play a central role in the maintenance of zinc homeostasis. Emerging evidence indicates important roles of zinc transporters in the regulation of various tissue functions. In this study, using the intestinal-epithelial specific or Lgr5-positive stem cell-specific ZIP7 deletion mice, we show that ZIP7 contribute to the maintenance of intestinal epithelial homeostasis by resolving ER stress in transit amplifying cells and intestinal stem cells.

Free Research Field

上皮生物学、亜鉛生物学