2016 Fiscal Year Final Research Report
The analysis of GPR120 pathway in colorectal tumor and establishment of EPA chemprevention
| Project/Area Number |
15K19342
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Gastroenterology
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| Research Institution | Yokohama City University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
NAKAJIMA Atsushi 横浜市立大学, 大学院医学研究科, 教授 (30326037)
UMEZAWA Shotaro 横浜市立大学, 医学研究科, 客員研究員 (90737678)
Uchiyama Shiori 横浜市立大学, 医学研究科, 客員研究員 (10714800)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Keywords | 大腸癌 / 化学予防 / GPR120 / EPA |
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| Outline of Final Research Achievements |
Colorectal Cancer (CRC) is increasing. Prevention for CRC, we analyzed the mechanism of GPR120 pathway that is considered the receptor of EPA, one of the omega-3 poly unsaturated fatty acids. EPA suppressed colorectal tumor in wild type mice, not suppressed in GPR120 knock out mice. EPA suppressed colorectal tumor by suppressing MAPK pathway via GPR120. In human, EPA suppressed rectal aberrant crypt foci. Through the research, we showed the probability of CRC chemoprevention using EPA.
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| Free Research Field |
大腸癌 化学予防
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