Translational research for activity of the hippocampus in cardiovascular diseases

2016 Fiscal Year Annual Research Report

• Project/Area Number: 15K19362
• Research Institution: Tohoku University
• Principal Investigator: 鈴木 秀明 東北大学, 医学系研究科, 非常勤講師 (20705462)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: 心不全 / たこつぼ心筋症 / 海馬 / MRI / うつ病 / 認知症 / ストレス

Outline of Annual Research Achievements

本研究は、研究1.心不全患者の脳活動に関する縦断研究、研究2.たこつぼ心筋症患者の脳活動に関する縦断研究、研究3.心疾患における海馬の異常の機序に関する研究、の三つの研究を行う予定で申請を行った。研究1については、2017年第81回日本循環器学会学術集会においてCirculation Journal Award 2016 Clinical Investigation部門優秀賞を受賞し、論文1,2として報告した。研究2については、脳幹病変とたこつぼ心筋症との関連について論文3として報告した。
論文1. Suzuki H, Matsumoto Y, et al. Reduced brain-derived neurotrophic factor is associated with cognitive dysfunction in patients with chronic heart failure. Geriatr Gerontol Int 2017 in press.
論文2. Suzuki H, Matsumoto Y, et al. Hippocampal Blood Flow Abnormality Associated With Depressive Symptoms and Cognitive Impairment in Patients With Chronic Heart Failure. Circ J 2016;80:1773-80.
論文3. Kozu K, Suzuki H, et al. Multiple sclerosis lesion in the medulla oblongata in a patient with takotsubo cardiomyopathy. Int J Cardiol 2016;222:980-1.

Research Products

• [Int'l Joint Research] University College London/Imperial College London(United Kingdom)
  • Country Name: United Kingdom
  • Counterpart Institution: University College London/Imperial College London
• [Journal Article] Delayed autonomic neuropathy in a patient with diethylene glycol poisoning: a case report (2017)
  • Author(s): 1. Kamada H, Suzuki H, Yamamoto S, Nomura R, Kushimoto S
  • Journal Title: Acutu Medicine and Surgery Volume: in press Pages: in press
  • DOI: 10.1002/ams2.267
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Reduced brain-derived neurotrophic factor is associated with cognitive dysfunction in patients with chronic heart failure (2017)
  • Author(s): Suzuki H, Matsumoto Y, Ota H, Sugimura K, Takahashi J, Ito K, Miyata S, Arai H, Taki Y, Furukawa K, Fukumoto Y, Shimokawa H
  • Journal Title: Geriatrics and Gerontology International Volume: in press Pages: in press
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Focal Reduction in Cardiac 123I-Metaiodobenzylguanidine Uptake in Patients with Anderson-Fabry Disease (2016)
  • Author(s): 2. Yamamoto S, Suzuki H, Sugimura K, Tatebe S, Aoki T, Miura M, Yaoita N, Sato H, Kozu K, Ota H, Takanami K, Takase K, Shimokawa H
  • Journal Title: Circulation Journal Volume: 80 Pages: 2550, 2551
  • DOI: 10.1253/circj.CJ-16-0690
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Multiple sclerosis lesion in the medulla oblongata in a patient with takotsubo cardiomyopathy (2016)
  • Author(s): Kozu K, Suzuki H, Nishiyama S, Yaoita N, Yamamoto S, Tatebe S, Miura M, Aoki T, Hao K, Matsumoto Y, Sugimura K, Aoki M, Shimokawa H
  • Journal Title: International Journal of Cardiology Volume: 222 Pages: 980, 981
  • DOI: 10.1016/j.ijcard.2016.08.128
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Effects of Balloon Pulmonary Angioplasty on Oxygenation in Patients with Chronic Thromboembolic Pulmonary Hypertension (2016)
  • Author(s): Aoki T, Sugimura K, Nochioka K, Miura M, Tatebe S, Yamamoto S, Yaoita N, Suzuki H, Sato H, Kozu K, Miyata S, Satoh K, Shimokawa H
  • Journal Title: Circulation Journal Volume: 80 Pages: 2227, 2234
  • DOI: 10.1253/circj.CJ-16-0254
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Dual-energy CT to estimate clinical severity of chronic thromboembolic pulmonary hypertension: Comparison with invasive right heart catheterization (2016)
  • Author(s): Takagi H, Ota H, Sugimura K, Otani Katharina, Tominaga J, Aoki T, Tatebe S, Miura M, Yamamoto Y, Sato H, Yaoita N, Suzuki H, Shimokawa H, Takase K
  • Journal Title: European Journal of Radiology Volume: 85 Pages: 1574, 1580
  • DOI: 10.1016/j.ejrad.2016.06.010
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Hippocampal Blood Flow Abnormality Associated With Depressive Symptoms and Cognitive Impairment in Patients With Chronic Heart Failure (2016)
  • Author(s): 7. Suzuki H, Matsumoto Y, Ota H, Sugimura K, Takahashi J, Ito K, Miyata S, Furukawa K, Arai H, Fukumoto Y, Taki Y, Shimokawa H
  • Journal Title: Circulation Journal Volume: 80 Pages: 1773, 1780
  • DOI: 10.1253/circj.CJ-16-0367
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Balloon Pulmonary Angioplasty Improves Biventricular Functions and Pulmonary Flow in Patients with Chronic Thromboembolic Pulmonary Hypertension (2016)
  • Author(s): Sato H, Ota H, Sugimura K, Aoki T, Tatebe S, Miura M, Miyamichi-Yamamoto S, Yaoita N, Suzuki H, Satoh K, Takase K, Shimokawa H
  • Journal Title: Circulation Journal Volume: 80 Pages: 1470, 1477
  • DOI: 10.1253/circj.CJ-15-1187
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Multiple Beneficial Effects of Balloon Pulmonary Angioplasty in Patients with Chronic Thromboembolic Pulmonary Hypertension (2016)
  • Author(s): Tatebe S, Sugimura K, Aoki T, Miura M, Nochioka K, Yamamoto S, Yaoita N, Suzuki H, Sato H, Satoh K, Fukumoto Y, Shimokawa H
  • Journal Title: Circulation Journal Volume: 80 Pages: 980, 988
  • DOI: 10.1253/circj.CJ-15-1187
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Chronic Thromboembolic Pulmonary Hypertension and Schizophrenia (2016)
  • Author(s): Suzuki H, Sugimura K, Tatebe S, Aoki T, Shimokawa H
  • Journal Title: International Journal of Cardiology Volume: 207 Pages: 363, 364
  • DOI: 10.1016/j.ijcard.2016.01.010
  • Peer Reviewed / Acknowledgement Compliant
• [Presentation] Hippocampus Abnormality is Associated with Depressive Symptoms and Cognitive Impairment in Patients with Chronic Heart Failure (2017)
  • Author(s): Suzuki H, Matsumoto Y, Ota H, Sugimura K, Takahashi J, Ito K, Miyata S, Furukawa K, Arai H, Fukumoto Y, Taki Y, Shimokawa H
  • Organizer: 第81回日本循環器学会学術集会
  • Place of Presentation: 石川県立音楽堂（石川県金沢市）
  • Year and Date: 2017-03-18 – 2017-03-18
  • Int'l Joint Research / Invited