Translational research for activity of the hippocampus in cardiovascular diseases

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K19362
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Cardiovascular medicine
• Research Institution: Tohoku University
• Principal Investigator: Suzuki Hideaki 東北大学, 医学系研究科, 非常勤講師 (20705462)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: 心不全 / たこつぼ心筋症 / 海馬 / MRI / うつ病 / 認知症 / ストレス

Outline of Final Research Achievements

Background: Brain and heart diseases adversely affect each other, called as heart-brain axis. Activity of the hippocampus is reduced in patients with depression and dementia.
Result 1: We showed cerebral blood flow in the hippocampus was lower in patients with heart failure, and was associated with depressive symptoms and cognitive dysfunction. Result 2: We showed blood brain-derived neurotrophic factor, which is associated with hippocampal activity, was lower in patients with heart failure, and was correlated with depressive symptoms and cognitive dysfunction. Result 3: We reported takotsubo cardiomyopathy, which is caused by mental and physical stress, was induced by an acute medullary lesion.

Free Research Field

循環器内科