Immune complexome analysis in patients with hypersensitivity pneumonia

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K19423
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Respiratory organ internal medicine
• Research Institution: Nagasaki University
• Principal Investigator: HARA Atsuko 長崎大学, 医歯薬学総合研究科(医学系), 客員研究員 (70736420)
• Research Collaborator: NAKASHIMA Shota ; HARADA Tatsuhiko ; TOMONAGA Masaomi ; YURA Hirokazu
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 夏型過敏性肺炎 / Human Apolipoprotein E / イムノコンプレキソーム解析法 / 気管支肺胞洗浄

Outline of Final Research Achievements

This study aimed to identify the antigens of hypersensitivity pneumonia by immune complexome analysis. Immune complexome analysis revealed Human Apolipoprotein E was frequently detected in bronchoalveolar lavage fluid in patients with summer type hypersensitivity pneumonia compared with disease controls. Furthermore, Human Apolipoprotein E levels in bronchoalveolar lavage fluid elevated compared with disease controls and were associated with clinical parameters in patients with summer type hypersensitivity pneumonia. These results suggest that Human Apolipoprotein E play a role in the pathogenesis of summer type hypersensitivity pneumonia.

Free Research Field

呼吸器内科学