2016 Fiscal Year Final Research Report
Functional elucidation and therapeutic application of protease in kidney injury by metabolic syndrome
| Project/Area Number |
15K19460
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Kidney internal medicine
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| Research Institution | Kumamoto University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2017-03-31
|
| Keywords | 尿蛋白 / メタボリックシンドローム / セリンプロテアーゼ |
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| Outline of Final Research Achievements |
Severe proteinuria observed in the High salt group were substantially attenuated by both Camostat and Hydralazine. The reduction levels in BP were comparable, but the anti-proteinuric effect of camostat was much greater than that of Hydralazine. High salt diet induced apoptosis of glomerular epitherial cells through activation of mineralocorticoid receptor. This study suggested that serine protease inhibitor attenuates apoptosis of glomerular epithelial cells and improves urinary protein. Taken together, camostat showed an anti-proteinuric effect by defending podocyte from apoptosis beyond its anti-hypertensive action.
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| Free Research Field |
腎臓内科
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