2016 Fiscal Year Final Research Report
Elucidation of demyelination mechanism caused by astrocyte injury
| Project/Area Number |
15K19473
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurology
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Keywords | アストロサイト / 脱髄 / 視神経脊髄炎 / アクアポリン４ / 炎症性サイトカイン / 虚血性組織障害 |
|---|
| Outline of Final Research Achievements |
In this study, we focused on two types of different pathology related to astrocytes injury. One is the effect on the myelin sheath caused by destruction and disappearance of astrocytes which typified by neuromyelitis optica spectrum disorders (NMOSD), and the other is a tissue dammage caused by reactive astrocytes seen in multiple sclerosis and other inflammatory demyelinating disease. As a result, the influence of astrocyte destruction itself is limited. On the other hand, we found inflammatory cytokines produced by reactive astrocytes exhibit a special pattern of myelin sheath damage.
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| Free Research Field |
神経免疫学
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