Identification of the mechanism of the development of nonalcoholic fatty liver disease in testosterone deficiency in men

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K19522
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Metabolomics
• Research Institution: Kyoto Prefectural University of Medicine
• Principal Investigator: Senmaru Takafumi 京都府立医科大学, 医学(系)研究科(研究院), 客員講師 (20637889)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: テストステロン低下 / 非アルコール性脂肪肝炎 / モデルマウス / インスリン抵抗性

Outline of Final Research Achievements

Orchiectomized mice fed high-fat diet showed decreased serum testosterone level, increased visceral fat, increased insulin resistance, increased serum inflammatory marker level, and hepatic fibrogenesis. These perturbations in the model mice were normalized to the levels of control mice by testosterone supplementation. Our results suggested that NASH is initiated by addition of chronic inflammation to fatty liver caused by testosterone deficiency and insulin resistance.

Free Research Field

内分泌・代謝