2016 Fiscal Year Final Research Report
analysis of pathogenesis of cognitive impairment focusing on receptor-binding brain protective molecule
| Project/Area Number |
15K19536
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Endocrinology
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| Research Institution | Yokohama City University |
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Principal Investigator |
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| Research Collaborator |
TAMURA Kouichi 横浜市立大学, 医学部, 教授 (40285143)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Keywords | 認知症 / 高血圧 |
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| Outline of Final Research Achievements |
We used Spontanously Hypertensive Rats (SHR) and angiotensin II-infused Wister Rats as hypertension/cognitive impairment model animals. We examined the regulation of central nerve ATRAP expression in the onset and development of hypertension and cognitive impairment. Compared with control rats, SHR and angiotensin II-infused rats exhibited the increase in oxidative stress in SFO and PVN, concomitant with a decrease in ATRAP/AT1 receptor ratio. These results indicate that down-regulation of ATRAP/AT1 receptor in SFO and PVN is involved in the onset and development of hypertension and cognitive impairment.
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| Free Research Field |
腎臓内科学
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