2016 Fiscal Year Final Research Report
Elucidation of significance of multiple genetic abnormalities and mechanism of acute transformation in myeloproliferative neoplasms
| Project/Area Number |
15K19554
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Hematology
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| Research Institution | University of Miyazaki |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Keywords | 骨髄増殖性腫瘍 / 急性転化 / JAK2 |
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| Outline of Final Research Achievements |
We generated mouse models having genetic abnormalities of JAK2 mutation (JAK2V617F), TET2 deficiency, CBFb-MYH11 fusion gene in double to triple. In the double abnormal models (JAK2/TET2 compound model and JAK2/CBFb-MYH11 compound model), acute transformation did not occur. In conclusion, two or more additional abnormalities are required for the acute transformation of JAK2 mutant myeloproliferative neoplasms. The triple abnormal model was created and analysis was started.
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| Free Research Field |
血液内科学
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