2017 Fiscal Year Final Research Report
The efficancy of calcium release-activated calcium channel inhitibors in the treatment of rheumatoid arthritis
| Project/Area Number |
15K19575
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Collagenous pathology/Allergology
|
|---|
| Research Institution | Ehime University |
|---|
Principal Investigator |
Liu Shuang 愛媛大学, 医学系研究科, 講師 (60403812)
|
|---|
| Project Period (FY) |
2015-04-01 – 2018-03-31
|
| Keywords | カルシウムチャネル阻害剤 / 免疫抑制剤 / 関節リウマチ / 抗体製剤 / 核酸製剤 / Short-hairpin RNA |
|---|
| Outline of Final Research Achievements |
In this study, the inhibitors of calcium release-activated calcium channel (CRAC), including small molecular compound YM-58483, neutralizing antibody, and shor-harpin RNA, were used to investigate the feasibility in the treatment of rheumatoid arthritis (RA). The efficacy of CRAC inhibitors was demonstrated according to the results of this study. The CRAC inhibitors are expected as a group of new globle immunosuppressants.
|
| Free Research Field |
薬理学
|
